In modern analytical labs, mass spectrometry has become essential. When you’re looking for an instrument that combines speed, resolution, and flexibility, Quadrupole Time-of-Flight Mass Spectrometry (Q-TOF) stands out as a top contender.
In this blog post, we’ll explain how the Q-TOF works, why it’s trusted in analytical labs worldwide, and highlight some Q-TOF MS models in our inventory with each offering unique strengths to support your research.
Q-TOF Is A Hybrid Mass Spectrometry Technique
Q-TOF MS combines the strengths of both quadrupole and time-of-flight (TOF) analyzers to deliver high-performance analytical capabilities. The quadrupole analyzer allows precise selection and fragmentation of ions, while the TOF analyzer offers high mass resolution and accuracy. Unlike ion traps, which focus primarily on mass resolution and accuracy, Q-TOF systems combine these qualities with a broad dynamic range, rapid acquisition speed, and in-spectrum ion detection without compromise.
The quadrupole mass analyzer separates ions based on their mass-to-charge ratio (m/z) by using electric fields to control ion motion. It consists of four metal rods, with radio frequency and direct current voltages applied to guide only ions with a specific m/z along a stable path. Ions that don’t match the selected m/z become unstable and are removed from the beam before going into the TOF analyzer. In a linear TOF analyzer, a highly accurate determination of the m/z is delivered because the flight time of the ion depends on the square root of the m/z. Some models use a reflectron TOF system to improve resolution. This reflectron corrects for differences in ion energy by adjusting their travel depth—ions with higher energy penetrate farther, allowing ions with the same m/z to reach the detector at nearly the same time. A schematic of the Q-TOF setup is below.
How Is Q-TOF Mass Spectrometry Used in the Real World?
Q-TOF as a powerful analytical tool is widely used across various scientific fields. Its versatility makes it indispensable for detailed molecular analysis, from complex biological samples to environmental and industrial testing. Here are some of the key applications where Q-TOF plays a critical role:
Applications of Q-TOF
Proteomics Research
Q-TOF enables precise identification and characterization of proteins, peptides, and post-translational modifications.
Metabolomics and Lipidomics Research
It is used to profile small molecules and discover biomarkers.
Pharmaceutical Research
It supports drug development, metabolites identification, and impurity analysis.
Environmental Testing
The technique enables sensitive detection and analysis of pollutants in air, water, and soil.
Food Safety
Q-TOF is applied to detect food contaminants and adulterants, as well as to verify the authenticity and quality of food products.
Forensics
It aids in toxicology screenings and trace evidence analysis.
Clinical Research
It supports biomarker analysis and personalized medicine.
Natural Product Research
The technology is used to discover and identify novel compounds from plants and other sources.
Background images from Unsplash
Popular Q-TOF Models Carried by SpectraLab Scientific
At SpectraLab Scientific, we stock a range of refurbished Q-TOF mass spectrometers backed by warranty and expert support. Each system is tested and validated to deliver peak performance at a fraction of the cost of new equipment.
Agilent 7200 Accurate-Mass Q-TOF GC/MS (G3851A) with Agilent 7890B and 7693A
Agilent 6550 iFunnel Q-TOF Mass Spectrometer
Sciex TripleTOF 6600 LC-MS System with Shimadzu UFLC Front-End
Waters Xevo G2-XS TOF Mass Spectrometer
Ready to Explore Q-TOF Solutions?
For laboratory staff, the Q-TOF is a way to unlock deeper insights without entering into Orbitrap-level costs. At SpectraLab Scientific, we offer not only systems but also expert advice, parts, and repair services to support your long-term success.
Talk to an expert from here or browse more Q-TOF options here.
